Health and Physical Activity - Grants
A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
Subcontract for Dr. Anita Coucoulas' grant in the Department of Surgery.
Dates: 5/16/2012 - 4/30/2013
Funding Amount: $123045.00
Funder: National Institutes of Health
Investigator: John Jakicic
Action for Health and Diabetes Brain Magnetic Resonance Imaging Ancillary Study
The Pittsburgh Site will engage in the following activities for this proposed study:
1. Conduct more extensive analyses of LookAHEAD Brain functional MRI data, adopting finer-grained reading protocols to compute novel outcomes that have greater specificity than the global measures currently being implemented in the LookAHEAD Brain Study.
2. Administer cognitive and physical function batteries to all eligible participants from the main LookAHEAD study.
3. Administer the NIH computer-assisted toolbox to assess cognitive function to all eligible participants from the main LookAHEAD Study.
4. Engage in manuscript and presentation development and submission to report the findings from this study.
5. Participate in study-wide related conference calls, meetings, etc.
Dates: 9/15/2012 - 8/31/2013
Funding Amount: $123368.00
Funder: National Institutes of Health
Investigator: John Jakicic
Action for Health in Diabetes Brain Magnetic Resonance Imaging Ancillary Study
This proposal will perform structural and functional magnetic resonance imaging (sMRI and fMRI) in 498 individuals aged 55-85 years, 10 years after they have been randomly assigned to either an ongoing effective Intensive Lifestyle Intervention (ILI) focused on weight loss and increased physical activity or a control condition referred to as Diabetes Support and Education (DSE). The project will also assess cognitive function and physical activity, adding to the weight data and expansive collateral measurements of Look AHEAD.
Dates: 9/15/2011 - 8/31/2012
Funding Amount: $263633.00
Funder: National Institutes of Health
Investigator: John Jakicic
CALERIE: Competitive Renewal: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
Subcontract with Duke University.
During the close-out phase of CALERIE, Dr. Rickman will assist in data analysis and manuscript preparation.
Dates: 8/1/2012 - 4/30/2013
Funding Amount: $16800.00
Funder: Duke University
Investigator: Amy Rickman
Decreased Fat Oxidation - Metabolic Inflexibility in African-American Women
Aims: 1) Determine fat oxidation during sub-maximal exercise in African American and Caucasian women; 2) Determine lipid accumulation and skeletal muscle characteristics (e.g. muscle fiber type, capillary density, oxidative capacity, mitochondrial content) that have been shown to be related to insulin sensitivity; and 3) Assess insulin sensitivity (peripheral and hepatic), and examine the relationship between insulin sensitivity, fat oxidation and skeletal muscle characteristics.
Dates: 6/1/2012 - 5/31/2013
Funding Amount: $76678.00
Funder: National Institutes of Health
Investigator: Paul Coen
Effects of Exercise and Weight Loss on Cardiovascular Health
The primary aim of this study is to examine the effect of the consensus public health recommended level of physical activity (moderate physical activity (MOD-PA) = 150 min/wk) versus higher dose of physical activity (high physical activity (High-PA) = 250 min/wk) in the context of a comprensive behavioral wieght loss program that includes a reduction in energy intake measures of cardiovascular function using cardiac MRI and biomarkers of vascular disease risk. Each of these exercise doses will be compared independently to a Diet Only group intervention on the proposed primary and secondary outcomes, with MOD-PA, also compared to High-PA. This study involves the recruitment of 390 overweight and obese adults who will be randomly assigned to one of the above conditions (Diet Only, MOD-PA, High-PA) for a period of 12 months.
Dates: 6/1/2012 - 5/31/2013
Funding Amount: $911199.00
Funder: National Institutes of Health
Investigator: John Jakicic
Enhanced Behavioral Intervention to Improve Long-Term Weight Loss in Yount Adults
This study will examine whether an enhanced weight loss intervention (EWLI) that includes technology components results in improved weight loss in young adults (18-34 years of age) compared to a standard behavioral weight loss study (SBWP) over a period of 24 months. This study will also examine whether EWLI, compared to SBWP, results in improved reductions in body fatness, improved reductions in body fat distribution, improved increases in fitness and physical activity, improved reductions in energy intake, or differences in behavioral/psychosocial measures.
Dates: 12/1/2012 - 11/30/2013
Funding Amount: $726687.00
Funder: National Institutes of Health
Investigator: John Jakicic
Influence of Physical Activity and Weight Loss on Brain Plasticity
This application proposes to add a neuroimaging arm to an NIH funded 12-month diet and physical activity intervention. Obesity is currenlty at epidemic proportions in the United States affecting over 1/3 of American adults. Impaired cognitive and brain function - manifested as mood disorders, impulsivity, and an increased risk for neurological pathology - are often unrecognized consequences of obesity.
Dates: 7/15/2012 - 6/30/2013
Funding Amount: $39113.00
Funder: National Institutes of Health
Investigator: John Jakicic
Intentional Weight Reduction adn Physical adn Cognitive Function
The University of Pittsburgh Look AHEAD site has been chosen to participate in this ancillary study, with the primary site being Wake Forest University, University Health Sciences. Specific aims of this ancillary study: 1) to obtain objective measures of physical function predictive of future disability in the Look AHEAD participants who are 60 years or older at their Year 8 visit; 2) to measure cognitive function in the Look AHEAD participants who are 60 years or older at their Year 8 visit, and 3) the analysis will also look at diabetic control in relation to functional outcomes, but the analysis would use measures already planned for collection in the parent study.
Dates: 9/1/2012 - 8/31/2013
Funding Amount: $31289.00
Funder: Wake Forest University Health Sciences
Investigator: John Jakicic
Intentional Weight Reductionand Physical andCognitive Function
The University of Pittsburgh Look AHEAD site has been chosen to participate in this ancillary study, with the primary site being Wake Forest University Health Sciences. Specific aims of this ancillary study:
1) To obtain objective measures of physical function predictive of future disability in the Look AHEAD participants who are 60 years or older at their Year 8 visit.
2) To measure cognitive function in the Look AHEAD participants who are 60 years or older at their Year 8 visit.
3) The analysis will also look at diabetic control in relation to functional outcomes, but the analysis would use measures already planned for collection in the parent study.
Dates: 9/1/2011 - 8/31/2012
Funding Amount: $100129.00
Funder: Wake Forest University Health Sciences
Investigator: John Jakicic
Look Ahead: Action for Health and Diabetes
We propose to perform structural and functional magnetic resonance imaging (sMRI and fMRI) in 498 individuals aged 55-85 years, 10 years after they have been randomly assigned to either an ongoing effective Intensive Lifestyle Intervention (ILI) focused on weight loss and increased physical activity or a control condition referred to as Diabetes Support and Education (DSE). We will also assess cognitive function and physical activity, adding to the weight data and expansive collateral measurements of Look AHEAD.
Dates: 8/1/2012 - 7/30/2013
Funding Amount: $1357425.00
Funder: National Institutes of Health
Investigator: John Jakicic
Look-AHEAD: Action for Health in Diabetes
Continuation
Dates: 8/1/2011 - 7/31/2012
Funding Amount: $385885.00
Funder: National Institutes of Health
Investigator: John Jakicic
Maximizing Adolescent Potentials Program (MAPS)
A comprehensive drug and alcohol prevention program for school-aged children and their families. MAPS operates several direct service programs and research projects for the prevention of substance abuse and promotion of mental health.
Dates: 7/1/2011 - 6/30/2012
Funding Amount: $371033.00
Funder: Allegheny County
Investigator: Carl Fertman
Maximizing Adolescent Potentials Program (MAPS)
A comprehensive drug and alcohol prevention program for school-aged children and their families. MAPS operates several direct service programs and research projects for the prevention of substance abuse and promotion of mental health.
Dates: 7/1/2012 - 6/30/2013
Funding Amount: $391767.00
Funder: Allegheny County
Investigator: Carl Fertman
Maximizing Adolescents Potentials Program (MAPS)
A comprehensive drug and alcohol prevention program for school-aged children and their families. MAPS operates several direct service programs and research projects for the prevention of substance abuse and promotion of mental health.
Dates: 1/1/2012 - 6/30/2012
Funding Amount: $5833.00
Funder: Allegheny County
Investigator: Carl Fertman
Physical Activity Following Surgery-Induced Weight Loss
Aim 1. Determine the effects of physical activity on changes in metabolic risk factors of obese patients following initial three-month weight loss from bariatric surgery.
Aim 2. Determine the effects of the addition of physical activity on intramyocellular lipid and other body composition changes following initial three-month bariatric surgery-induced weight loss.
Dates: 2/1/2012 - 1/31/2013
Funding Amount: $99323.00
Funder: National Institutes of Health
Investigator: John Jakicic
Preoperative Lifestyle Intervention in Bariatric Surgery
Dates: 9/1/2011 - 8/31/2012
Funding Amount: $16219.00
Funder: National Institutes of Health
Investigator: John Jakicic
School Mental Health Services
The services will be to provide school-based prevention education, early intervention and support services to select elementary schools.
Dates: 9/27/2012 - 6/7/2013
Funding Amount: $3840.00
Funder: Pittsburgh Public Schools
Investigator: Carl Fertman
School-Based Service Project
The services provided will include ongoing educational/awareness groups, alternative activities, referral to community agencies and consulting services.
Dates: 9/1/2011 - 8/31/2012
Funding Amount: $72000.00
Funder: Central Catholic High School
Investigator: Carl Fertman
Skeletal Muscle Lipid and Insulin Resistance in Aging
The age-associated loss in skeletal muscle mass, sarcopenia, is associated with impairments in muscle strength and power generating capacity, limitations in function, and ultimately physical disability and institutionalization. It has become increasingly clear, however, that progressive muscle weakness likely contributing to the functional decline with aging cannot be solely attributed to sarcopenia. We have recenlty reported in longitudinal studies tha the loss of strength is ~3X greater than the loss of muscle mass in older men and women. Therefore, age-related changes in muscle mass and muscle "quality," defined by strength per unit muscle size, that is, specific torque, may each contribute separately to the loss of muscle function in old age.
Dates: 9/30/2011 - 8/31/2012
Funding Amount: $46844.00
Funder: National Institutes of Health
Investigator: Paul Coen
Skeletal Muscle Lipid and Insulin Resistance in Aging
Dates: 9/1/2012 - 8/31/2013
Funding Amount: $29326.00
Funder: National Institutes of Health
Investigator: Paul Coen
Student Mental Health Promotion Project
Dates: 9/1/2011 - 8/31/2012
Funding Amount: $165000.00
Funder: Shaler Area School District
Investigator: Carl Fertman
Student Mental Health Promotion Project
Dates: 9/1/2011 - 8/31/2012
Funding Amount: $495000.00
Funder: Fox Chapel School District
Investigator: Carl Fertman
Student Mental Health Promotion Project
This project will provide drug and alcohol prevention and mental health promotion services to the Fox Chapel Area School District.
Dates: 9/1/2012 - 8/31/2013
Funding Amount: $522250.00
Funder: Fox Chapel School District
Investigator: Carl Fertman
Student Mental Health Promotion Project
This project will provide drug and alcohol prevention and mental health promotion services to the Shaler Area School District.
Dates: 9/1/2012 - 8/31/2015
Funding Amount: $174500.00
Funder: Shaler Area School District
Investigator: Carl Fertman
Summer Food Service Program
The Summer Food Service Program (SFSP) is an important source of supplementary funding to help cover the cost of providing more than 120 disadvantaged children with a daily lunch in conjunction with their participation in educational and sports activity at the University.
The SFSP helps replace the nutritional deficits that might be experienced by children who are out of school during the summer, and thus benefitting from free or reduced price school lunch programs.
Dates: 7/1/2011 - 6/30/2012
Funding Amount: $6604.49
Funder: Pennsylvania Department of Education
Investigator: Martha Pristas
The Effect of a Stepped-Care Approach to Long-Term Weight Loss
Dates: 7/1/2011 - 6/30/2012
Funding Amount: $1340605.00
Funder: National Institutes of Health
Investigator: John Jakicic
The Effect of a Stepped-Care Approach to Long-Term Weight Loss
This study will examine whether a chronic-care obesity intervention delivered in a "stepped-care" manner results in improved weight loss compared to a standard behavioral weight loss intervention; results in improved reductions in body fat distribution compared to a standard behavioral weight loss intervention; results in improved reductions in energy intake compared to a standard behavioral weight loss intervention; results in an improved increase in physical activity compared to a standard behavioral weight loss intervention; to examine if there are differences between the interventions for self-efficacy, outcome expectations, barriers, motivation and other behavioral/psychosocial measures and examine the cost-effectiveness of a chronic-care obesity intervention.
Dates: 7/1/2011 - 6/30/2012
Funding Amount: $790491.00
Funder: National Heart Lung and Blood Institute
Investigator: John Jakicic
Violence Prevention Program
This project will implement the blueprint for Violence prevention program - Strengthening Families 10-14 in the McKeesport community.
Dates: 7/1/2011 - 6/30/2012
Funding Amount: $56292.00
Funder: Pennsylvania Commission on Crime
Investigator: Carl Fertman